STAT3 Expression in Host Myeloid Cells Controls GVHD Severity.

Evelyn C Nieves,Tomomi Toubai,Daniel C Peltier,Katherine Oravecz-Wilson,Chen Liu,Hiroya Tamaki,Yaping Sun,Pavan Reddy

Biology of Blood and Marrow Transplantation（2017）

引用 7|浏览9

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摘要

•STAT3 negatively regulates macrophage responses.•Expression of STAT3 in host-derived myeloid cells, such as macrophages and neutrophils, restrains alloimmune responses and reduces GVHD severity.•Expression of STAT3 in donor-derived myeloid cells is dispensable for GVHD severity.

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关键词

Bone marrow transplantation,Graft-versus-host disease,STAT-3,Myeloid cells

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