A single dose of the novel chimeric subunit vaccine E2-CD154 confers early full protection against classical swine fever virus.

Marisela Suárez,Yusmel Sordo, Yanet Prieto,María P Rodríguez,Lídice Méndez,Elsa M Rodríguez,Alina Rodríguez-Mallon,Elianet Lorenzo,Elaine Santana,Nemecio González,Paula Naranjo,María Teresa Frías,Yamila Carpio,Mario Pablo Estrada

Vaccine（2017）

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摘要

•A stable HEK 293 cell line was generated to produce E2-CSFV antigen fused to CD154.•The E2-CD154 protein was secreted into the medium in suspension culture.•The E2-CD154 obtained was glycosylated and mainly forming protein aggregates.•First report of a subunit vaccine conferring protection 7days after single dose.•Specific anti-CSFV neutralizing antibodies and IFN-γ were induced 8 dpc (14dpv).

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关键词

CD154,Classical swine fever virus,glycoprotein E2,HEK 293,Lentiviral vectors

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