In Vitro Pharmacodynamic Effects of Cangrelor on Platelet P2Y12 Receptor-Mediated Signaling in Ticagrelor-Treated Patients.

Fabiana Rollini,Francesco Franchi,Estela Thano, Gabriel Faz,Yongwhi Park,Megha Kureti,Jung Rae Cho,Latonya Been,Theodore A Bass,Dominick J Angiolillo

JACC: Cardiovascular Interventions（2017）

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摘要

In high-risk acute coronary syndrome patients undergoing percutaneous coronary intervention, the pharmacodynamic (PD) effects of ticagrelor and prasugrel are subject to variability in response profiles in the early hours after drug administration [(1)][1]. In particular, 2 to 4 h may be required

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