Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion

Sathishkumar Kurusamy,Dolores López-Maderuelo,Robert Little, David Cadagan,Aaron M. Savage, Jude C. Ihugba, Rhiannon R. Baggott, Farjana B. Rowther,Sara Martínez-Martínez,Pablo Gómez-del Arco, Clare Murcott,Weiguang Wang,J. Francisco Nistal,Delvac Oceandy,Ludwig Neyses,Robert N. Wilkinson,Elizabeth J. Cartwright,Juan Miguel Redondo,Angel Luis Armesilla

Journal of Molecular and Cellular Cardiology（2017）

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摘要

•Aurintricarboxylic acid (ATA) disrupts the PMCA4/calcineurin interaction.•Inhibition of PMCA4 with ATA increases VEGF-activated calcineurin/NFAT signalling.•ATA enhances VEGF-induced endothelial cell motility and tubular morphogenesis.•ATA improves post-ischaemic hind limb reperfusion in vivo.

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关键词

PMCA4,Angiogenesis,ATA,Calcineurin/NFAT,VEGF

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