Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling

•Largest pharmacokinetic study of chloroquine (CQ) and its active metabolite desethylchloroquine (DCQ) in pregnancy.•Pregnancy significantly reduced exposure to CQ and DCQ.•Azithromycin modestly increased DCQ but not CQ exposure.•Higher CQ doses are needed in pregnancy for treatment of acute malaria.•Even larger doses may be needed for intermittent preventive treatment in pregnancy.