Evaluation of 5 Commercially Available Zika Virus Immunoassays.

David Safronetz,Angela Sloan,Derek R Stein,Emelissa Mendoza,Nicole Barairo,Charlene Ranadheera,Leanne Scharikow, Kimberly Holloway,Alyssia Robinson,Maya Traykova-Andonova,Kai Makowski,Kristina Dimitrova,Elizabeth Giles,Joanne Hiebert, Rhonda Mogk, Sharla Beddome,Michael Drebot

EMERGING INFECTIOUS DISEASES（2017）

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摘要

Because of the global spread of Zika virus, accurate and high-throughput diagnostic immunoassays are needed. We compared the sensitivity and specificity of 5 commercially available Zika virus serologic assays to the recommended protocol of Zika virus IgM-capture ELISA and plaque-reduction neutralization tests. Most commercial immunoassays showed low sensitivity, which can be increased.

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关键词

Canada,ELISA,IgM,IgM-capture ELISA,MAC-ELISA,Zika virus,evaluation,immunoassays,sensitivity,specificity,vector-borne infections,viruses,zoonoses

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