Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.

Sabin Llona-Minguez,Maria Häggblad,Ulf Martens,Lars Johansson,Kristmundur Sigmundsson,Thomas Lundbäck,Olga Loseva,Ann-Sofie Jemth,Bo Lundgren,Annika Jenmalm Jensen,Martin Scobie,Thomas Helleday

Bioorganic & Medicinal Chemistry Letters（2017）

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摘要

Two screening campaigns using commercial (Chembridge DiverSET) and proprietary (Chemical Biology Consortium Sweden, CBCS) compound libraries, revealed a number of pyridone- and pyrimidinone-derived systems as inhibitors of the human dCTP pyrophosphatase 1 (dCTPase). In this letter, we present their preliminary structure-activity-relationships (SAR) and ligand efficiency scores (LE and LLE).

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关键词

DCTPP1,Nucleotide metabolism,Pyridone,Pyrimidone

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