Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses.

Takashi Matsuwaki,Kiseko Shionoya,Robert Ihnatko,Anna Eskilsson,Shigeru Kakuta,Sylvie Dufour,Markus Schwaninger,Ari Waisman,Werner Müller,Emmanuel Pinteaux,David Engblom,Anders Blomqvist

Brain, Behavior, and Immunity（2017）

引用 22|浏览12

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摘要

•IL-1R1 deletion reduces LPS-induced fever but not anorexia or HPA-axis activation.•IL-1R1s on brain endothelial cells are involved in the febrile response to LPS.•IL-1R1s on neural cells or peripheral nerves are not critical for LPS induced fever.

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关键词

Interleukin-1 type 1 receptor,Lipopolysaccharide,Fever,Anorexia,ACTH,Corticosterone,Endothelial cells,TNFα,Interleukin-6,PGE2

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