Andrographolide-loaded nanoparticles for brain delivery: formulation, characterisation and in vitro permeability using hCMEC/D3 cell line.

Clizia Guccione,Mouhssin Oufir,Vieri Piazzini,Daniela Elisabeth Eigenmann,Evelyn Andrea Jähne,Volha Zabela,Maria Teresa Faleschini,Maria Camilla Bergonzi,Martin Smiesko,Matthias Hamburger,Anna Rita Bilia

European Journal of Pharmaceutics and Biopharmaceutics（2017）

引用 35|浏览18

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摘要

•Andrographolide was loaded into albumin and poly-ethylcyanoacrylate nanoparticles.•Size, zeta-potential, polydispersity and morphology were investigated.•Blood brain barrier permeability was assessed using in vitro cell based model.•UPLC-MS/MS method was developed and validated according to EMA/FDA guidelines.•Albumin nanoparticles improved permeation maintaining the integrity of cell layer.

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关键词

AG,ATM,BBB,BSA,CNS,DLS,DMSO,ECA,EE,EMA,ESI-,ESI,EtOH,FA,FDA,h,hCMEC/D3,HSA NPs,HSA,HSAC AG NPs,HSAT AG NPs,IS,LC,LLOQ,LogP,LRP1,MRM,NaCl,Papp,PBS,PDI,Pe,PECA NPs,PS,PSA,QCH,QCL,QCM,QCs,RHB,SS,TEM,TFA,TW80,ULOQ,UPLC-MS/MS,WS2,WSs,Zh,ζ potential

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