Heterogeneous epigenetic regulation of HACE1 in Burkitt- Lymphoma-derived cells

Abdelilah Bouzelfen,Hafid Kora,Marion Alcantara,Philippe Bertrand,Jean-Baptiste Latouche,Fabrice Jardin

Leukemia Research（2017）

引用 5|浏览8

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摘要

•DZNep treatment increased HACE1 gene expression.•Histone methylation (H3K9me2/H3K27me3) of the HACE1 promoter concomitantly decreased.•HACE1 can be downregulated by methylation of its promoter region chromatin.•CpG88 was enriched for H3K27me3 and H3K9me2 whereas CpG177 was enriched for H3K9me2.

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关键词

3-Deazaneplanocin a,Burkitt- lymphoma-derived cells,HACE1,Histone methylation,DNA methylation,Epigenetics

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