Treatment of neurocognitive symptoms in unipolar depression: A systematic review and future perspectives.

•Cognitive dysfunction in major depressive disorder (MDD) is becoming a major concern.•We reviewed a broad number of interventions targeting cognitive symptoms of MDD.•Agents focusing on the glutamate system and neuroinflammation are being tested.•There are some promising pharmacological, physical and psychological therapies.•To date, there is no compelling data to draw any firm conclusion on this issue.