Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders
NATURE NEUROSCIENCE(2017)
摘要
Using large-scale analysis of protein interactions and bioinformatics, Li et al . describe the organization of the core-scaffold machinery of the postsynaptic density and its assembly in protein-interaction networks. The authors show how mutations associated with complex brain disorders are distributed along spatiotemporal protein complexes and modulate their protein interactions.
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关键词
Cellular neuroscience,Proteome
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