Anti-androgenic mechanisms of Bisphenol A involve androgen receptor signaling pathway.

Hui Wang,Zhen Ding,Qiao-Mei Shi,Xing Ge,Heng-Xue Wang,Meng-Xue Li,Gang Chen,Qi Wang,Qiang Ju,Jin-Peng Zhang,Mei-Rong Zhang,Li-Chun Xu

Toxicology（2017）

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摘要

The mechanisms responsible for AR antagonism of BPA involve inhibiting the AR N/C interaction and enhancing the interactions of AR-SMRT and AR-NCoR. BPA may interfere with the AR signaling to exhibit anti-androgenic activity.

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关键词

AR,BPA,EDCs,DHT,AREs,N/C,SRC-1,SMRT,NCoR,HDACs,CCK-8,RTCA,CAT,β-gal

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