Cyclooxygenase-2 promotes pulmonary intravascular macrophage accumulation by exacerbating BMP signaling in rat experimental hepatopulmonary syndrome.

Chang Liu,Jing Gao, Bing Chen,Lin Chen,Karine Belguise,Weifeng Yu,Kaizhi Lu,Xiaobo Wang,Bin Yi

Biochemical Pharmacology（2017）

引用 18|浏览5

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摘要

•COX-2/PGE2 signaling is strongly activated in lung after CBDL.•COX-2/PGE2 activation after CBDL promotes the development of HPS via macrophage accumulation.•The BMP-2/CV-2 imbalance induced BMP signaling promotes macrophage accumulation after CBDL.•COX-2/PGE2 signaling promotes the imbalance of BMP-2/CV-2 in PMVECs and lung.•Parecoxib improves HPS by the inhibition of BMP-2/CV-2 imbalance and macrophage accumulation, indicating its clinical value.

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关键词

HPS,COX-2,BMP-2,CV-2,CBDL,PGE2,PMVEC,IPVD,i-NOS,VEGF,PDGF,PCNA,VWF,EP

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