Accumulation of porphyrins in Propionibacterium acnes by 5-aminolevulinic acid and its esters

Arisa Ogata,Yuya Hasunuma, Emii Kikuchi,Takuya Ishii,Masahiro Ishizuka,Yoshikazu Tokuoka

Photodiagnosis and Photodynamic Therapy（2017）

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摘要

•ALA is superior to ALA esters in accumulating porphyrins in P.acnes.•PDT efficacy for P.acnes is greater than by ALA than by ALA esters.•Peptidoglycans in cell wall of P.acnes could make uptake of ALA esters difficult.

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关键词

5-Aminolevulinic acid,5-Aminolevulinic acid esters,P.acnes,Porphyrin accumulation,PDT efficacy

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