Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women

    Ryan Cheu
    Ryan Cheu
    Michelle Perner
    Michelle Perner
    Laura Noël-Romas
    Laura Noël-Romas
    Anneke Grobler
    Anneke Grobler
    Irene Y. Xie
    Irene Y. Xie
    Jennifer Butler
    Jennifer Butler

    science, Volume 356, Issue 6341, 2017, Pages 938-945.

    Cited by: 94|Bibtex|Views0|Links
    WOS SCIENCE

    Abstract:

    Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women. We investigated whether vaginal microbiota modulated tenofovir gel microbicide efficacy in the CAPRISA (Centre for the AIDS Program of Research in South Africa) 004 trial. Two major vaginal bacterial community types—one dominated by Lactobacillus...More

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