Global survey of the immunomodulatory potential of common drugs

Gregory I Vladimer,Berend Snijder,Nikolaus Krall,Johannes W Bigenzahn,Kilian V M Huber,Charles-Hugues Lardeau,Kumar Sanjiv,Anna Ringler,Ulrika Warpman Berglund, Monika Sabler,Oscar Lopez de la Fuente,Paul Knöbl,Stefan Kubicek,Thomas Helleday,Ulrich Jäger,Giulio Superti-Furga

NATURE CHEMICAL BIOLOGY（2017）

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摘要

high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the physical interactions among peripheral mononuclear leukocytes revealed known immunomodulators and also approved drugs as regulators of unexpected targets, including MST1R.

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关键词

Cancer therapy,Cancer therapy,Immunology,High-throughput screening,Phenotypic screening

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