Modeling of the catalytic core of Arabidopsis thaliana Dicer-like 4 protein and its complex with double-stranded RNA

Agnieszka Mickiewicz,Joanna Sarzyńska,Maciej Miłostan,Anna Kurzyńska-Kokorniak,Agnieszka Rybarczyk,Piotr Łukasiak,Tadeusz Kuliński,Marek Figlerowicz,Jacek Błażewicz

Computational Biology and Chemistry（2017）

引用 11|浏览17

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摘要

•Plant Dicer-like proteins have Platform domain similar to Giardia and human Dicers.•Assembling of the AtDCL-dsRNA complex was performed using NMA and template-based approaches.•The arrangement of the Platform and PAZ domains, rather than the length of the Connector, are responsible for the size of Dicer products.

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关键词

RNAi,siRNA,siRNA biogenesis,Dicer-like proteins,Homology modeling,PAZ,RNase III

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