The temperature effect on cardiac ryanodine receptor gating and conductance: Mathematical modeling

The temperature effect on cardiac ryanodine receptor (RyR) function has been studied within the electron-conformational (EC) model. It’s shown that a simple EC model with an Arrhenius-like temperature dependence of the “internal” and “external” frictions and a specific thermosensitivity of the tunnelling “open↔closed” transitions can provide both qualitative and quantitative description of the temperature effects for isolated RyRs. The potential of the model was illustrated by explaining the experimental data on the temperature dependence of isolated sheep cardiac RyR gating and conductance (R. Sitsapesan et al., J. Physiol. 434 , 469(1991)).