Forward genetic screen of human transposase genomic rearrangements

Anton G. Henssen,Eileen Jiang,Jiali Zhuang,Luca Pinello,Nicholas D. Socci,Richard Koche,Mithat Gonen,Camila M. Villasante,Scott A. Armstrong,Daniel E. Bauer,Zhiping Weng,Alex Kentsis

BMC Genomics（2016）

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摘要

Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities on endogenous genomic substrates.

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关键词

Inverted Terminal Repeat,Thioguanine,HPRT1 Gene,Recombination Signal Sequence,Short Tandem Repeat Analysis

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