Correction: Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

Muhammad Hasan Bashari,Fengjuan Fan,Sonia Vallet,Martin Sattler, Melissa Arn,Claudia Luckner-Minden,Henning Schulze-Bergkamen,Inka Zörnig,Frederik Marme,Andreas Schneeweiss,Michael H. Cardone,Joseph T. Opferman,Dirk Jäger,Klaus Podar

Breast Cancer Research（2024）

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摘要

Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Here we investigated the pathophysiologic role of Mcl-1 in Her2-positive BC cells under hypoxic conditions.

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关键词

Breast cancer,Myeloid cell leukemia-1,Hypoxia,Apoptosis

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