The multiple drug resistance gene, MDR1: Expression at the protein and RNA levels

Ya Qin Li,Venu Gopal,Pratibha S Amare Kadam,Shawn Files,Harvey D Preisler

Medical Oncology and Tumor Pharmacotherapy（1992）

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摘要

A comparison of three different approaches to detect MDR1 expression in myeloid leukemia cells was undertaken. With respect to the 4 different antibodies studied, a high proportion of false positive reactions were detected. Substantial discordance between MDR1 expression as indicated by Northern blot analysis, PCR, and immunohistochemistry was found. These findings complicate the clinical interpretation of data derived from these methods.

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关键词

Monoclonal antibodies, Multiple drug resistance, Myeloid Leukemia, Northern blot analysis, Polymerase chain reaction, Southern blot analysis

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