Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease

Jelena Klawitter,Iram Zafar,Jost Klawitter,Alexander T Pennington,Jacek Klepacki,Berenice Y Gitomer,Robert W Schrier,Uwe Christians,Charles L Edelstein

BMC Nephrology（2013）

引用 15|浏览1

暂无评分

摘要

We previously demonstrated that lovastatin decreases cyst volume and improves kidney function in the Han:SPRD (Cy/+) rat model of ADPKD. Since endothelial dysfunction and inflammatory activity are evident in patients with ADPKD, we investigated whether lovastatin reduces the inflammation and vascular dysfunction and improves kidney cell energy metabolism of Cy/+ rats.

查看译文

关键词

PKD Han:SPRD rat model,Lovastatin,Biomarkers,Inflammation,Endothelial dysfunction

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要