Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy

Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a retrospective study to review a total of 227 patients of dyssynchronous heart failure underwent CRT implantation. Logistic analysis was performed between CRT responders and CRT non-responders. The primary outcome was the occurrence of improved left ventricular ejection fraction 1 year after CRT implantation. We concluded that LVEDV > 255 mL ( OR = 2.236; 95 % CI, 1.016 – 4.923 ) rather than LVESV > 160 mL ( OR = 1.18; 95 % CI, 0.544 – 2.56 ) and TpTe/QTc > 0.203 ( OR = 5.206; 95 % CI, 1.89 – 14.34 ) significantly predicted CRT non-response. Oppositely, S wave > 5.7 cm/s ( OR = 0.242; 95 % CI, 0.089 – 0.657 ), E/A > 1 ( OR = 0.211; 95 % CI, 0.079 – 0.566 ), E’/A’ > 1 ( OR = 0.054; 95 % CI, 0.017 – 0.172 ), CLBBB ( OR = 0.141; 95 % CI, 0.048 – 0.409 ), and QRS duration >160 ms ( OR = 0.52; 95 % CI, 0.305 – 0.922 ) surprisingly predicted low-probability of CRT non-response.