A Review on the NLRP3 Inflammasome and Stroke

Inflammasome pattern recognition receptors belong to the family of multi-meric proteins, plays an important role in innate immunity, including NLRPs, NLRC, and NAIP. In which, NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome may activate the inflammation and the participation of atherosclerosis, pathophysiology of myocardial infarction, ischemia/reperfusion injury and stroke and other cardiovascular diseases. Effective regulation of NLRP3 may help prevent and treat stroke. In recent years, the role of inflammation in stroke has attracted much attention, and the in-depth study of its mechanism of action is gradually clear. This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of stroke.