Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel

NATURE MEDICINE（2017）

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摘要

Intracellular trafficking of the voltage-gated cardiac Na + channel Nav1.5 is regulated by lysine deacetylation mediated by Sirt1, thereby affecting sodium current and cardiac electrical activity.

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Arrhythmias,Preclinical research

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