Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer Giannicola Genovese , Alessandro Carugo , James Tepper , Frederick Scott Robinson , Liren Li , Maria Svelto , Luigi Nezi , Denise Corti , Rosalba Minelli , Piergiorgio Pettazzoni , Tony Gutschner , Chia-Chin Wu , Sahil Seth , Kadir Caner Akdemir , Elisabetta Leo , Samirkumar Amin , Marco Dal Molin , Haoqiang Ying , Lawrence N. Kwong , Simona Colla , Koichi Takahashi , Papia Ghosh , Virginia Giuliani , Florian Muller , Prasenjit Dey , Shan Jiang , Jill Garvey , Chang-Gong Liu , Jianhua Zhang , Timothy P. Heffernan , Carlo Toniatti , Jason B. Fleming , Michael G. Goggins , Laura D. Wood , Alessandro Sgambato , Abbas Agaimy , Anirban Maitra , Charles W. M. Roberts , Huamin Wang , Andrea Viale , Ronald A. DePinho , Giulio F. Draetta , Lynda Chin NATURE（2017）
摘要
Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly aggressive Kras-independent pancreatic cancer cells to develop.
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Cancer models, Cancer epigenetics
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