A distinct innate lymphoid cell population regulates tumor-associated T cells

Sarah Q Crome,Linh T Nguyen,Sandra Lopez-Verges,S Y Cindy Yang,Bernard Martin,Jennifer Y Yam,Dylan J Johnson,Jessica Nie, Michael Pniak,Pei Hua Yen,Anca Milea,Ramlogan Sowamber, Sarah Rachel Katz,Marcus Q Bernardini,Blaise A Clarke,Patricia A Shaw,Philipp A Lang,Hal K Berman,Trevor J Pugh,Lewis L Lanier,Pamela S Ohashi

NATURE MEDICINE（2017）

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摘要

previously uncharacterized population of innate lymphoid cells (ILCs) in the tumor microenvironment limits T cell expansion and cytokine production, and associates with early recurrence in patients with cancer. Depletion of this regulatory immunosuppressive cell population overcomes this effect, suggesting important implications for cancer immunotherapy.

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关键词

Immunosurveillance,Translational immunology,Innate lymphoid cells,Immunosuppression

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