HTS-compatible FRET-based conformational sensors clarify membrane receptor activation

Pauline Scholler,David Moreno-Delgado, Nathalie Lecat-Guillet,Etienne Doumazane,Carine Monnier,Fabienne Charrier-Savournin,Ludovic Fabre, Cédric Chouvet,Stéphanie Soldevila,Laurent Lamarque, Geoffrey Donsimoni,Thomas Roux,Jurriaan M Zwier,Eric Trinquet,Philippe Rondard,Jean-Philippe Pin

NATURE CHEMICAL BIOLOGY（2017）

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摘要

Optimizing the signal-to-noise ratio in time-resolved FRET through generation of agonist-responsive cell-surface receptor biosensors, including GABA B receptors and EGFR, which are useful for monitoring conformational changes associated with receptor activation.

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关键词

Pharmacology,Drug screening,Membranes,Chemical tools

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