SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

Rebecca Kring Hansen,Andreas Mund, Sara Lund Poulsen,Maria Sandoval,Karolin Klement,Katerina Tsouroula,Maxim A. X. Tollenaere,Markus Räschle,Rebeca Soria,Stefan Offermanns,Thomas Worzfeld,Robert Grosse,Dominique T. Brandt,Björn Rozell,Matthias Mann,Francesca Cole,Evi Soutoglou,Aaron A. Goodarzi,Jeremy A. Daniel,Niels Mailand,Simon Bekker-Jensen

NATURE CELL BIOLOGY（2016）

引用 30|浏览7

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摘要

Hansen et al. find that SCAI (suppressor of cancer cell invasion) is a 53BP1-binding protein that acts to repair in heterochromatin and to facilitate meiotic recombination in germ cells.

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关键词

DNA damage and repair,DNA recombination,Meiosis

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