Small-molecule factor D inhibitors targeting the alternative complement pathway
NATURE CHEMICAL BIOLOGY(2016)
摘要
fragment-based design approach identifies reversible inhibitors targeting human protease complement factor D (FD), which is required for amplification of complement C3 signaling. FD inhibitors act as systemic regulators of complement activation in vivo .
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关键词
Structure-based drug design,Immunological disorders,Chemical tools,Immunology
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