Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence

Huiqing Zheng,Christopher J Colvin,Benjamin K Johnson,Paul D Kirchhoff,Michael Wilson, Katriana Jorgensen-Muga,Scott D Larsen,Robert B Abramovitch

NATURE CHEMICAL BIOLOGY（2016）

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摘要

high-throughput screen identifies inhibitors of the M. tuberculosis dormancy regulation system, DosRST, including compounds that inhibit autophosphorylation of the DosS and DosT sensor kinases and those that inhibit the catalytic heme of these kinases.

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关键词

Mechanism of action,Bacteria,Phenotypic screening,High-throughput screening

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