Recruitment of calcineurin to the TCR positively regulates T cell activation

Debjani Dutta,Valarie A Barr,Itoro Akpan,Paul R Mittelstadt,Laishram I Singha,Lawrence E Samelson,Jonathan D Ashwell

Nature immunology（2016）

引用 62|浏览0

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摘要

The phosphatase calcineurin targets NFAT transcription factors in T cells. Ashwell and colleagues show that calcineurin is recruited to the TCR signaling complex, where it reverses the inhibitory phosphorylation of the kinase Lck.

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关键词

T-cell receptor,Signal transduction

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