ADARB1 catalyzes circadian A-to-I editing and regulates RNA rhythm

Hideki Terajima,Hikari Yoshitane,Haruka Ozaki,Yutaka Suzuki,Shigeki Shimba,Shinya Kuroda,Wataru Iwasaki,Yoshitaka Fukada

Nature genetics（2016）

引用 65|浏览2

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摘要

Yoshitaka Fukada, Hikari Yoshitane and colleagues report that rhythmic expression of ADARB1, an RNA-editing enzyme that catalyzes adenosine-to-inosine conversion, controls mRNA oscillations in the mouse liver. Mice with Adarb1 mutations exhibit short-period rhythms in locomotor activity and gene expression.

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关键词

Transcriptomics,Gene expression profiling,Gene regulation

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