The modularity and dynamicity of miRNA–mRNA interactions in high-grade serous ovarian carcinomas and the prognostic implication

•We establish a unique landscape of miRNA–mRNA interaction networks in the cells of serous ovarian carcinomas.•We find that miRNA–mRNA modules with strong connections are relatively stable in cancer development and progression.•We show that network-oriented modeling of miRNA–mRNA interactions can facilitate the identification of robust prognostic biomarkers for ovarian cancer.