Oxidative guanine base damage regulates human telomerase activity

Elise Fouquerel,Justin Lormand,Arindam Bose,Hui-Ting Lee,Grace S Kim,Jianfeng Li,Robert W Sobol,Bret D Freudenthal,Sua Myong,Patricia L Opresko

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2016）

引用 131|浏览3

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摘要

Opposing effects of 8-oxodGTP on telomerase activity – promoting elongation by destabilizing G4 structures or inhibiting elongation by acting as a chain terminator – explain the differential sensitivity of cells with short telomeres to oxidative stress.

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关键词

Enzyme mechanisms,Chromosomes,DNA adducts

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