Non-classical transpeptidases yield insight into new antibacterials

Pankaj Kumar,Amit Kaushik,Evan P Lloyd,Shao-Gang Li,Rohini Mattoo,Nicole C Ammerman,Drew T Bell,Alexander L Perryman,Trevor A Zandi,Sean Ekins,Stephan L Ginell,Craig A Townsend,Joel S Freundlich,Gyanu Lamichhane

NATURE CHEMICAL BIOLOGY（2016）

引用 82|浏览28

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摘要

Carbapenem β-lactam antibiotics target non-classical transpeptidases, the L,D -transpeptidases, which act in an alternative Mycobacterium tuberculosis peptidoglycan synthesis pathway, informing the design of evolved carbapenems with improved antibacterial activity.

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关键词

Enzymes,Carbohydrates,Drug discovery,Bacteria

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