Propylparaben reduces the excitability of hippocampal neurons by blocking sodium channels.

Leonardo Lara-Valderrábano,Luisa Rocha,Emilio J Galván

NeuroToxicology（2016）

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摘要

•Perfusion of PPB alters electrophysiological properties of hippocampal cells.•PPB blocks the persistent and the fast-inactivating sodium currents.•PPB decreases the intrinsic excitability and modifies the action potential kinetics.•Higher concentrations of PPB suppresses the spike activity.

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关键词

Propylparaben,Neuronal excitability,Sodium currents,CA1 pyramidal cells

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