Xenografting of Cancer Cell Lines for In Vivo Screening of the Therapeutic Potential of HDAC Inhibitors.

Daniel Nettersheim,Sina Jostes,Hubert Schorle

HDAC/HAT FUNCTION ASSESSMENT AND INHIBITOR DEVELOPMENT: METHODS AND PROTOCOLS（2017）

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摘要

Histone deacetylase inhibitor application is lethal to many cancer types. To screen for the therapeutic potential of HDIs it is necessary to analyze their ability to target and kill cancer cells in vivo. Here, we describe the xenografting of (germ cell) cancer cell lines into the flank of nude mice and the subsequent intravenous application of HDIs.

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关键词

Cancer cell lines,HDAC inhibitors,In vivo vein injection,Therapy,Xenografting

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