Function of Cryopreserved MSCs with and without IFN-γ pre-licensing is Context Dependent.

Tailoring MSCs to fit the disease. Fresh, cryopreserved and, pre-licensed cryopreserved MSC are all being explored to treat numerous diseases, but all are not suitable to treat all conditions. CLI: Critical limb ischemia, OI: osteogenesis imperfecta, GvHD: graft versus host disease, I/R: ischemia reperfusion (I/R) injury. '*' denotes preferred therapeutic strategy when both fresh MSC and cryo-MSC have shown utility in treating the disease but one is more efficacious or logistically suitable.