Selective functional activity measurement of a PEGylated protein with a modification-dependent activity assay.

Alfred Weber,Andrea Engelmaier, Gabriele Mohr, Sonja Haindl,Hans Peter Schwarz,Peter L Turecek

Journal of Pharmaceutical and Biomedical Analysis（2017）

引用 4|浏览9

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摘要

•Selective measurement of PEGylated factor VIII in presence of non-modified factor VIII.•Determination of the functional activity of a PEGylated drug.•Unambiguous assignment of functional activity to the PEGylated drug.•The concept can be extended to other enzymes and modifications.

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关键词

Activity assay,PEGylated drug,Pharmacokinetic

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