Cobalt(II)-Catalyzed Aerobic Oxidation of Terminal-Capped Alkynyl α‑Cyano Alkanone Systems. An Oxygen-Mediated Radical Chain Reaction
JOURNAL OF ORGANIC CHEMISTRY(2016)
摘要
A new N-hydroxyphthalimide (NHPI)/Co(II)-catalyzed protocol, mechanistically involving a sequence of a hydrogen abstraction, 5-exo-dig cyclization, oxygen capture, hydrogen transfer, and 1,4-dehydration, has been developed to facilitate aerobic oxidation of aryl-, silyl-, and alkyl-capped alkynyl alpha-cyano alkanone systems to the corresponding highly functionalized products in an effective manner, thus turning this novel chain reaction, originally occurring spontaneously in low yields, into a practical methodology.
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