Relationship Of Liver X Receptors Alpha And Endoglin Levels In Serum And Placenta With Preeclampsia

BackgroundLiver X receptor alpha (LXR alpha) and endoglin have been postulated to play roles in trophoblast invasion and lipid metabolic disturbances. However, the relationship between LXR alpha and endoglin levels in serum and placenta of patients with preeclampsia remains poorly understood. The objective of this study was to identify correlations between LXR alpha, endoglin and preeclampsia and provide new feasible methods of clinical prediction and treatment for preeclampsia.MethodsWe enrolled 45 patients with preeclampsia (24 with moderate preeclampsia and 21 with severe preeclampsia) and 15 normal pregnant women (control group) who were admitted to the Department of Obstetrics of the General Hospital of Beijing Command between October 2012 and July 2013 in this study. Serum and placental LXR alpha and endoglin levels were analyzed by enzyme-linked immunosorbent assay, real-time quantitative PCR, tissue microarray and immunohistochemistry.ResultsSerum and placental LXR alpha and endoglin levels were significantly higher in patients with preeclampsia than those in control group (P<0.05, each). Moreover, patients with severe preeclampsia displayed significantly higher LXR alpha and endoglin levels than those with moderate preeclampsia (P<0.05, each). The LXR alpha sensitivity, specificity and positive and negative predictive values were 66.00%, 80.00%, 89.19% and 48.48%, respectively, while those of endoglin levels were 62.00%, 85.00%, 91.18% and 47.22%, respectively. LXR alpha and endoglin levels in serum and placenta from patients with preeclampsia were positively correlated (serum: r = 0.486, P<0.01; placenta: r = 0.569, P<0.01).ConclusionsElevated LXR alpha and endoglin levels may be associated with preeclampsia pathogenesis and development and could be used as potential predictors for this disorder.