Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Tycho E. T. Mevissen,Yogesh Kulathu,Monique P.C. Mulder,Paul P. Geurink,Sarah L. Maslen,Malte Gersch,Paul R. Elliott,John E. Burke,Bianca D. M. van Tol,Masato Akutsu,Farid El Oualid,Masato Kawasaki,Stefan M.V. Freund,Huib Ovaa,David Komander

NATURE（2016）

引用 142|浏览26

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摘要

The structures of the deubiquitinating enzyme Cezanne alone or in complex with its substrate or product are solved, showing how Cezanne specifically targets Lys11-linked polyubiquitin.

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关键词

Enzyme mechanisms,Ubiquitylation,X-ray crystallography,Science,Humanities and Social Sciences,multidisciplinary

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