TAK-063, a phosphodiesterase 10A inhibitor, modulates neuronal activity in various brain regions in phMRI and EEG studies with and without ketamine challenge.

Yoshiro Tomimatsu,Diana Cash,Motohisa Suzuki,Kazunori Suzuki,Michel Bernanos,Camilla Simmons,Steven C R Williams,Haruhide Kimura

Neuroscience（2016）

引用 17|浏览4

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摘要

•[3H]TAK-063 highly accumulated in the striatum and substantia nigra.•TAK-063 modified the phMRI-BOLD signal beyond the localization of PDE10A in rats.•TAK-063 suppressed the ketamine-induced cortical EEG activation in rats and monkeys.•TAK-063 modulated ketamine-induced BOLD changes in various brain regions in rats.

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关键词

Amy,ARG,AUC,BOLD,Bs,cAMP,Cb,cGMP,CNS,CPu,EEG,Fcx,FFT,Hipp,ic,MSNs,NMDA,PDE10A,phMRI,PSL,SN,VP

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