SF2312 is a natural phosphonate inhibitor of enolase

Paul G Leonard,Nikunj Satani,David Maxwell,Yu-Hsi Lin,Naima Hammoudi,Zhenghong Peng,Federica Pisaneschi,Todd M Link,Gilbert R Lee IV,Duoli Sun,Basvoju A Bhanu Prasad,Maria Emilia Di Francesco,Barbara Czako,John M Asara,Y Alan Wang,William Bornmann,Ronald A DePinho,Florian L Muller

NATURE CHEMICAL BIOLOGY（2016）

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摘要

SF2312, a phosphonate antibiotic, directly binds and inhibits the activity of the glycolytic enzyme enolase and is selectively toxic to ENO1 -deleted glioma cells through inhibition of glycolysis and depletion of ATP.

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关键词

Cancer therapy,Metabolic pathways,Natural products,Target identification,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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