The genomic landscape of schwannoma

NATURE GENETICS（2016）

引用 111|浏览40

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摘要

Gelareh Zadeh, Kenneth Aldape and colleagues present an integrative genomic analysis of schwannomas. In addition to finding recurrent mutations in ARID1A , ARID1B and DDR1 , they identify a recurrent SH3PXD2A - HTRA1 fusion that confers increased proliferation, invasion and in vivo transformation, and is associated with sensitivity to MEK inhibition.

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关键词

CNS cancer,DNA sequencing,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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