TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons

Xavier Caubit, Paolo Gubellini,Joris Andrieux,Pierre L Roubertoux,Mehdi Metwaly,Bernard Jacq,Ahmed Fatmi,Laurence Had-Aissouni,Kenneth Y Kwan,Pascal Salin,Michèle Carlier,Agne Liedén, Eva Rudd,Marwan Shinawi,Catherine Vincent-Delorme,Jean-Marie Cuisset,Marie-Pierre Lemaitre, Fatimetou Abderrehamane, Bénédicte Duban, Jean-François Lemaitre,Adrian S Woolf,Detlef Bockenhauer,Dany Severac,Emeric Dubois,Ying Zhu,Nenad Sestan,Alistair N Garratt,Lydia Kerkerian-Le Goff,Laurent Fasano

NATURE GENETICS（2016）

引用 61|浏览6

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摘要

Laurent Fasano and colleagues identify TSHZ3 deletions in patients with autism spectrum disorder. Tshz3 -mutant mice show functional changes at synapses established by cortical projection neurons and exhibit autism-like behavioral patterns.

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关键词

Neurodevelopmental disorders,Neuroscience,Neurogenesis,Gene regulation

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