An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

Weiyue Zheng, Masataka Umitsu, Ishaan Jagan,Charles W. Tran,Noboru Ishiyama,Michael BeGora,Kiyomi Araki,Pamela S. Ohashi,Mitsuhiko Ikura,Senthil K. Muthuswamy

NATURE CELL BIOLOGY（2016）

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摘要

Muthuswamy et al. report that in macrophages SCRIB interacts with the NADPH oxidase complex to promote the production of reactive oxygen species needed to kill bacteria. Conversely, loss of SCRIB promotes M1 macrophage polarization and inflammation.

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关键词

Cell polarity,Phagocytosis

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