Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract
NATURE IMMUNOLOGY(2016)
摘要
lveolar macrophages help maintain lung-tissue homeostasis despite constant microbial exposure. Zhang and colleagues show that the E3 ligase TRIM29 suppresses excessive proinflammatory responses by targeting the adaptor NEMO in alveolar macrophages.
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nature immunology,science
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